PROJECT #16456 RESEARCH FOR Î’-LACTMASES
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

This project studies the E240D mutant of Tem-1 β-Lactmase

β-Lactmases are enzymes which break down penicillin-like antibiotics. This is the most common method by which bacteria become resistant to such antibiotics. This project is simulating the most probable common ancestor (dating back to around 2 billion years ago) of modern day Gram Negative beta-lactamases. We hope to understand the funtional significance of various cryptic pockets found in these enzymes by comparing these results to simulations of modern beta-lactamases. Finding such functional pockets could enable us to target these enzymes with drugs that might combat this form of antibiotic resistance.

PROJECT INFO

Manager(s): Sukrit Singh

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 33,222

Core: GRO_A7

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Friday, 30 July 2021 00:39:51

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Folding@Home Identifier
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Model
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PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Friday, 30 July 2021 00:39:51

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN 9 3950X 16-CORE 32 11,700 374,400 AMD
2 RYZEN 9 3900X 12-CORE 24 14,068 337,632 AMD
3 RYZEN THREADRIPPER 2950X 16-CORE 32 6,692 214,144 AMD
4 RYZEN THREADRIPPER 1920X 12-CORE 24 7,123 170,952 AMD
5 RYZEN 7 2700X EIGHT-CORE 16 9,740 155,840 AMD
6 RYZEN 7 5800X 8-CORE 16 8,265 132,240 AMD
7 RYZEN 7 3700X 8-CORE 16 7,935 126,960 AMD
8 RYZEN 5 3600 6-CORE 12 8,539 102,468 AMD
9 RYZEN 3 3100 4-CORE 8 10,398 83,184 AMD
10 RYZEN 5 3500 6-CORE 6 13,329 79,974 AMD
11 XEON CPU E5-2690 V2 @ 3.00GHZ 20 3,475 69,500 Intel
12 XEON CPU E5-2630 0 @ 2.30GHZ 24 2,727 65,448 Intel
13 RYZEN 5 4600HS 12 5,053 60,636 AMD
14 CORE2 DUO CPU T7700 @ 2.40GHZ 12 4,704 56,448 Intel
15 RYZEN 5 2600 SIX-CORE 12 3,559 42,708 AMD
16 CORE I7-4790 CPU @ 3.60GHZ 8 4,508 36,064 Intel
17 CORE I5-7300HQ CPU @ 2.50GHZ 4 2,856 11,424 Intel
18 A8-6410 APU 4 85 340 AMD