PROJECT #16456 RESEARCH FOR Î’-LACTMASES
FOLDING PERFORMANCE PROFILE
PROJECT SUMMARY
This project studies the E240D mutant of Tem-1 β-Lactmase
β-Lactmases are enzymes which break down penicillin-like antibiotics. This is the most common method by which bacteria become resistant to such antibiotics. This project is simulating the most probable common ancestor (dating back to around 2 billion years ago) of modern day Gram Negative beta-lactamases. We hope to understand the funtional significance of various cryptic pockets found in these enzymes by comparing these results to simulations of modern beta-lactamases. Finding such functional pockets could enable us to target these enzymes with drugs that might combat this form of antibiotic resistance.
PROJECT INFO
Manager(s): Sukrit Singh
Institution: Washington University in St. Louis
PROJECT WORK UNIT SUMMARY
Atoms: 33,222
Core: GRO_A7
Status: Public
PROJECT FOLDING PPD AVERAGES BY GPU
PPDDB data as of Friday, 30 July 2021 00:39:51
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Rank Project |
Model Name Folding@Home Identifier |
Make Brand |
GPU Model |
PPD Average |
Points WU Average |
WUs Day Average |
WU Time Average |
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PROJECT FOLDING PPD AVERAGES BY CPU BETA
PPDDB data as of Friday, 30 July 2021 00:39:51
|
Rank Project |
CPU Model |
Logical Processors (LP) |
PPD-PLP AVG PPD per 1 LP |
ALL LP-PPD (Estimated) |
Make |
|---|---|---|---|---|---|
| 1 | RYZEN 9 3950X 16-CORE | 32 | 11,700 | 374,400 | AMD |
| 2 | RYZEN 9 3900X 12-CORE | 24 | 14,068 | 337,632 | AMD |
| 3 | RYZEN THREADRIPPER 2950X 16-CORE | 32 | 6,692 | 214,144 | AMD |
| 4 | RYZEN THREADRIPPER 1920X 12-CORE | 24 | 7,123 | 170,952 | AMD |
| 5 | RYZEN 7 2700X EIGHT-CORE | 16 | 9,740 | 155,840 | AMD |
| 6 | RYZEN 7 5800X 8-CORE | 16 | 8,265 | 132,240 | AMD |
| 7 | RYZEN 7 3700X 8-CORE | 16 | 7,935 | 126,960 | AMD |
| 8 | RYZEN 5 3600 6-CORE | 12 | 8,539 | 102,468 | AMD |
| 9 | RYZEN 3 3100 4-CORE | 8 | 10,398 | 83,184 | AMD |
| 10 | RYZEN 5 3500 6-CORE | 6 | 13,329 | 79,974 | AMD |
| 11 | XEON CPU E5-2690 V2 @ 3.00GHZ | 20 | 3,475 | 69,500 | Intel |
| 12 | XEON CPU E5-2630 0 @ 2.30GHZ | 24 | 2,727 | 65,448 | Intel |
| 13 | RYZEN 5 4600HS | 12 | 5,053 | 60,636 | AMD |
| 14 | CORE2 DUO CPU T7700 @ 2.40GHZ | 12 | 4,704 | 56,448 | Intel |
| 15 | RYZEN 5 2600 SIX-CORE | 12 | 3,559 | 42,708 | AMD |
| 16 | CORE I7-4790 CPU @ 3.60GHZ | 8 | 4,508 | 36,064 | Intel |
| 17 | CORE I5-7300HQ CPU @ 2.50GHZ | 4 | 2,856 | 11,424 | Intel |
| 18 | A8-6410 APU | 4 | 85 | 340 | AMD |
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