PROJECT #16454 RESEARCH FOR UNSPECIFIED
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

This project studies the R241F mutant of Tem-1 β-Lactmase

β-Lactmases are enzymes which break down penicillin-like antibiotics. This is the most common method by which bacteria become resistant to such antibiotics. This project is simulating the most probable common ancestor (dating back to around 2 billion years ago) of modern day Gram Negative beta-lactamases. We hope to understand the funtional significance of various cryptic pockets found in these enzymes by comparing these results to simulations of modern beta-lactamases. Finding such functional pockets could enable us to target these enzymes with drugs that might combat this form of antibiotic resistance.

PROJECT INFO

Manager(s): Sukrit Singh

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 33,296

Core: GRO_A7

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Monday, 18 January 2021 21:10:09

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 HD Graphics 4000
[HD Graphics 4000]
Intel 657 514 1.28 19 hrs 47 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Monday, 18 January 2021 21:10:09

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN THREADRIPPER 3960X 24-CORE 48 12,484 599,232 AMD
2 RYZEN 9 3950X 16-CORE 32 12,521 400,672 AMD
3 RYZEN 9 3900X 12-CORE 24 12,477 299,448 AMD
4 RYZEN 9 3900XT 12-CORE 24 9,609 230,616 AMD
5 RYZEN 7 5800X 8-CORE 16 12,812 204,992 AMD
6 CORE I9-10980XE CPU @ 3.00GHZ 36 5,620 202,320 Intel
7 XEON CPU E5-2686 V4 @ 2.30GHZ 36 4,866 175,176 Intel
8 RYZEN 7 3700X 8-CORE 16 10,677 170,832 AMD
9 CORE I9-7920X CPU @ 2.90GHZ 24 6,855 164,520 Intel
10 RYZEN THREADRIPPER 1920X 12-CORE 24 6,680 160,320 AMD
11 CORE I9-9900KF CPU @ 3.60GHZ 16 10,016 160,256 Intel
12 CORE I9-10900X CPU @ 3.70GHZ 20 7,425 148,500 Intel
13 CORE I9-9900K CPU @ 3.60GHZ 16 9,231 147,696 Intel
14 CORE I9-7940X CPU @ 3.10GHZ 28 4,471 125,188 Intel
15 RYZEN 5 3600 6-CORE 12 10,110 121,320 AMD
16 CORE I7-8700K CPU @ 3.70GHZ 12 9,379 112,548 Intel
17 RYZEN 5 3600X 6-CORE 12 8,457 101,484 AMD
18 XEON CPU E5-2660 0 @ 2.20GHZ 32 3,098 99,136 Intel
19 RYZEN 7 2700X EIGHT-CORE 16 4,950 79,200 AMD
20 RYZEN 5 2600X SIX-CORE 12 5,717 68,604 AMD
21 XEON CPU E5-2690 V2 @ 3.00GHZ 20 3,403 68,060 Intel
22 RYZEN 5 2600 SIX-CORE 12 5,556 66,672 AMD
23 CORE I3-10100 CPU @ 3.60GHZ 8 7,152 57,216 Intel
24 CORE I5-9400 CPU @ 2.90GHZ 6 8,314 49,884 Intel
25 CORE I7-4790K CPU @ 4.00GHZ 8 5,734 45,872 Intel
26 PHENOM II X6 1090T 6 3,995 23,970 AMD
27 RYZEN 5 3500U 8 1,050 8,400 AMD
28 CORE2 DUO CPU T8100 @ 2.10GHZ 2 1,255 2,510 Intel
 

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