PROJECT #16449 RESEARCH FOR CANCER
FOLDING PERFORMANCE PROFILE
PROJECT SUMMARY
This project seeks to understand G protein inhibition in the treatment of uveal melanoma and other G protein related diseases.
G proteins are molecular switches regulate biological functions like sight, smell, and memory.
This pivotal role makes G proteins essential players in physiology and pathophysiology.
However, when G proteins mutate, they result in a variety of diseases from cancer to heart disease.
For example, a single mutation in the Gq protein is known to cause uveal melanoma, a cancer in the iris of our eyes that remains largely untreatable short of removing the eye. This project is simulating one of the G protein family isoforms, GPA1, found in Arabidopsis thaliana.
GPA1 is distinct from the other G proteins in our body, in that it is "switch-like" behavior is not regulated by membrane receptors (GPCRs).
While other projects are simulating human G proteins to understand their similarities and differences, studying GPA1 provides an "extreme" example of a G protein most dissimilar from the rest.
Understanding GPA1 relative to other G proteins has implications in knowing G protein evolution and G protein disease pathology.
PROJECT INFO
Manager(s): Sukrit Singh
Institution: Washington University in St. Louis
PROJECT WORK UNIT SUMMARY
Atoms: 66,723
Core: GRO_A7
Status: Public
PROJECT FOLDING PPD AVERAGES BY GPU
PPDDB data as of Tuesday, 07 February 2023 12:15:00
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PROJECT FOLDING PPD AVERAGES BY CPU BETA
PPDDB data as of Tuesday, 07 February 2023 12:15:00
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1 | RYZEN 9 3950X 16-CORE | 32 | 12,224 | 391,168 | AMD |