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The proteasome subunit hRpn13 is a critical component of cell maintenance and reproduction, serving to help recruit ubiquitinated targets for protein degradation.
Inhibitors of hRpn13 are a promising avenue for anti-cancer therapeutics. This project aims to simulate the Pru domain of hRpn13 which contains many different surfaces at which interactions with proteins and peptides occur, and undergoes significant conformational change upon binding.
Compare community-sampled Folding@Home output for the GPUs and CPUs processing this project.
|
Rank Project |
CPU Model |
Logical Processors (LP) |
PPD-PLP AVG PPD per 1 LP |
ALL LP-PPD (Estimated) |
Make |
|---|---|---|---|---|---|
| 1 | RYZEN AI MAX 395 W/ RADEON 8060S | 32 | 31,453 | 1,006,496 | AMD |
| 2 | RYZEN 9 7945HX | 32 | 28,834 | 922,688 | AMD |
| 3 | RYZEN 9 9950X3D 16-CORE | 32 | 20,230 | 647,360 | AMD |
| 4 | RYZEN 5 5500 | 12 | 20,229 | 242,748 | AMD |
| 5 | CORE I5-10400 CPU @ 2.90GHZ | 12 | 12,895 | 154,740 | Intel |
| 6 | CORE I9-8950HK CPU @ 2.90GHZ | 12 | 11,158 | 133,896 | Intel |
| 7 | CORE I5-10500T CPU @ 2.30GHZ | 12 | 10,951 | 131,412 | Intel |
| 8 | CORE I7-8700 CPU @ 3.20GHZ | 12 | 9,479 | 113,748 | Intel |
| 9 | XEON CPU E3-1270 V5 @ 3.60GHZ | 8 | 11,165 | 89,320 | Intel |
| 10 | XEON W-2125 CPU @ 4.00GHZ | 8 | 10,327 | 82,616 | Intel |
| 11 | RYZEN 7 7800X3D 8-CORE | 16 | 5,163 | 82,608 | AMD |
| 12 | XEON CPU X5667 @ 3.07GHZ | 8 | 2,536 | 20,288 | Intel |