PROJECT #16918 FOLDING AT HOME PPD DATABASE

FOLDING FOR: CANCER

PPDDB data as of Thursday, 29 October 2020 20:04:27

PROJECT SUMMARY

FOX01 is a human forkhead transcription factor involved in insulin signaling. Mutations in this protein have been found in Diffuse Large B-Cell Lymphoma (DLBCL) patient’s cell lines, and associated with decreased survival in DLBCL patients.

Do these mutations affect the folding of FOX01, or disrupt the binding of FOX01 to DNA?  As part of our efforts to answer this question, we are performing all-atom simulations of wild type FOX01 to examine the folding landscape of this system. Understanding how mutations affect the regulatory function of this transcription factor will help elucidate the role of FOX01 in the development of DLBCL, and may provide insight for the development of new therapeutics.

PROJECT INFO

Manager(s): Dylan Novack

Institution: Temple University

Project URL: http://voelzlab.org

PROJECT WORK UNIT SUMMARY

Atoms: 65,536

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

Model Make GPU PPD
(Average)
Points WU
(Average)
WUs Day
(Average)
WU Time
(Average)
GeForce RTX 3090 Nvidia GA102 5,133,962 280,918 18.28 1 hrs 19 mins
GeForce RTX 3080 10GB / 20GB Nvidia GA102 4,239,005 261,558 16.21 1 hrs 29 mins
Tesla V100 SXM2 16GB Nvidia GV100GL 4,063,209 260,978 15.57 2 hrs 32 mins
GeForce RTX 2080 Ti Rev. A Nvidia TU102 3,992,431 257,164 15.52 2 hrs 33 mins
TITAN RTX Nvidia TU102 3,830,123 250,422 15.29 2 hrs 34 mins
GeForce RTX 2080 Ti Nvidia TU102 3,053,944 236,388 12.92 2 hrs 51 mins
GeForce RTX 2080 Super Nvidia TU104 2,715,819 227,806 11.92 2 hrs 1 mins
TITAN Xp Nvidia GP102 2,678,289 221,638 12.08 2 hrs 59 mins
GeForce RTX 2070 SUPER Nvidia TU104 2,127,451 206,836 10.29 2 hrs 20 mins
GeForce RTX 2080 Nvidia TU104 2,124,186 209,593 10.13 2 hrs 22 mins
GeForce RTX 2070 SUPER Nvidia TU104 2,057,471 203,203 10.13 2 hrs 22 mins
Quadro RTX 6000/8000 Nvidia TU102GL 2,033,455 207,025 9.82 2 hrs 27 mins
GeForce GTX 1080 Ti Nvidia GP102 2,027,146 205,697 9.86 2 hrs 26 mins
GeForce RTX 2060 Super Nvidia TU106 1,829,265 198,721 9.21 3 hrs 36 mins
GeForce RTX 2070 Rev. A Nvidia TU106 1,807,052 196,906 9.18 3 hrs 37 mins
GeForce RTX 2060 KO Nvidia TU106-200A 1,804,577 199,249 9.06 3 hrs 39 mins
GeForce RTX 2080 SUPER Mobile / Max-Q Nvidia TU104BM 1,734,402 196,726 8.82 3 hrs 43 mins
GeForce RTX 2080 SUPER Mobile / Max-Q Nvidia TU104M 1,666,176 191,234 8.71 3 hrs 45 mins
GeForce RTX 2080 Rev. A Nvidia TU104 1,528,497 149,469 10.23 2 hrs 21 mins
Quadro RTX 4000 Nvidia TU104GL 1,438,173 184,815 7.78 3 hrs 5 mins
GeForce GTX 1080 Nvidia GP104 1,424,187 182,685 7.80 3 hrs 5 mins
GeForce RTX 2060 Nvidia TU104 1,417,703 182,100 7.79 3 hrs 5 mins
GeForce RTX 2060 Nvidia TU106 1,397,251 182,004 7.68 3 hrs 8 mins
GeForce RTX 2060 Mobile Nvidia TU106M 1,366,108 181,832 7.51 3 hrs 12 mins
GeForce GTX 1070 Ti Nvidia GP104 1,357,113 181,181 7.49 3 hrs 12 mins
GeForce RTX 2070 Nvidia TU106 1,166,555 162,369 7.18 3 hrs 20 mins
GeForce GTX 1660 Ti Nvidia TU116 1,083,548 167,756 6.46 4 hrs 43 mins
Radeon VII AMD Vega 20 1,056,622 165,873 6.37 4 hrs 46 mins
GeForce GTX 1660 SUPER Nvidia TU116 1,046,724 165,233 6.33 4 hrs 47 mins
Radeon RX 5600/5600 XT - 5700/5700 XT AMD Navi 10 935,503 157,945 5.92 4 hrs 3 mins
GeForce GTX 980 Ti Nvidia GM200 871,124 155,645 5.60 4 hrs 17 mins
Tesla T4 Nvidia TU104GL 864,007 155,833 5.54 4 hrs 20 mins
GeForce GTX 1070 Nvidia GP104 840,413 151,949 5.53 4 hrs 20 mins
Radeon RX Vega 56/64 AMD Vega 10 XL/XT 827,952 152,690 5.42 4 hrs 26 mins
GeForce GTX 1070 Mobile Nvidia GP104M 790,648 129,631 6.10 4 hrs 56 mins
GeForce RTX 2060 Mobile / Max-Q Nvidia TU106M 731,521 146,589 4.99 5 hrs 49 mins
GeForce GTX 1660 Nvidia TU116 656,532 135,827 4.83 5 hrs 58 mins
Quadro P4200 Mobile Nvidia GP104GLM 652,464 134,074 4.87 5 hrs 56 mins
GeForce GTX 1060 6GB Nvidia GP106 608,525 137,961 4.41 5 hrs 26 mins
GeForce GTX 1650 SUPER Nvidia TU116 604,228 137,284 4.40 5 hrs 27 mins
GeForce GTX 1650 Ti Mobile Nvidia TU116M 565,597 135,508 4.17 6 hrs 45 mins
GeForce GTX 980 Nvidia GM204 549,060 125,621 4.37 5 hrs 29 mins
GeForce GTX 970 Nvidia GM204 525,781 131,360 4.00 6 hrs 60 mins
GeForce GTX 1650 Nvidia TU116 501,896 129,857 3.86 6 hrs 13 mins
GeForce GTX 1060 3GB Nvidia GP106 479,331 121,613 3.94 6 hrs 5 mins
P104-100 Nvidia GP104 448,366 125,310 3.58 7 hrs 42 mins
Radeon RX 470/480/570/580/590 AMD Ellesmere XT 416,776 121,483 3.43 7 hrs 60 mins
GeForce GTX 1650 Mobile / Max-Q Nvidia TU117M 407,693 120,760 3.38 7 hrs 7 mins
Radeon R9 Fury X AMD Fiji XT 402,862 118,282 3.41 7 hrs 3 mins
Quadro P2200 Nvidia GP106GL 382,920 119,219 3.21 7 hrs 28 mins
P106-100 Nvidia GP106 343,196 114,586 3.00 8 hrs 1 mins
GeForce GTX 1050 Ti Nvidia GP107 311,787 110,729 2.82 9 hrs 31 mins
GeForce GTX 960 Nvidia GM206 300,668 108,336 2.78 9 hrs 39 mins
Radeon R9 200/300 Series AMD Hawaii 289,700 106,352 2.72 9 hrs 49 mins
P106-090 Nvidia GP106 278,134 106,643 2.61 9 hrs 12 mins
GeForce GTX 1050 LP Nvidia GP107 258,560 104,231 2.48 10 hrs 40 mins
Radeon R9 280/HD 7900/8950 AMD Tahiti PRO 229,861 100,710 2.28 11 hrs 31 mins
Quadro T1000 Mobile Nvidia TU117GLM 229,552 99,720 2.30 10 hrs 26 mins
Radeon R9 200/300X Series AMD Hawaii 226,712 91,384 2.48 10 hrs 40 mins
GeForce GTX 660 Ti Nvidia GK104 183,271 90,665 2.02 12 hrs 52 mins
GeForce GTX 1650 Nvidia TU117 175,252 84,399 2.08 12 hrs 33 mins
GeForce GT 1030 Nvidia GP108 156,531 81,160 1.93 12 hrs 27 mins
Radeon RX Vega M XL AMD Vega 138,392 84,951 1.63 15 hrs 44 mins
GeForce GTX 680 Nvidia GK104 132,398 82,066 1.61 15 hrs 53 mins
Polaris11 AMD Baffin 126,608 82,196 1.54 16 hrs 35 mins
Radeon HD 7800 AMD Pitcairn 122,737 81,287 1.51 16 hrs 54 mins
Radeon R9 200 Series AMD Hawaii 106,091 76,488 1.39 17 hrs 18 mins
GeForce GTX 750 Ti Nvidia GM107 96,111 75,061 1.28 19 hrs 45 mins
GeForce GTX 770 Nvidia GK104 90,959 73,711 1.23 19 hrs 27 mins
Radeon RX 460 AMD Baffin XT 80,944 61,760 1.31 18 hrs 19 mins
GeForce GTX 760 Nvidia GK104 69,561 67,357 1.03 23 hrs 14 mins
GeForce GTX 960M Nvidia GM107 54,712 46,346 1.18 20 hrs 20 mins
Ryzen vega 8 mobile AMD Raven 45,773 47,680 0.96 25 hrs 60 mins
Quadro P400 Nvidia GP107GL 44,187 57,280 0.77 31 hrs 7 mins
GeForce GTX 560 Ti Nvidia GF114 31,244 51,598 0.61 40 hrs 38 mins
GeForce GTX 460 v2 Nvidia GF114 23,897 47,213 0.51 47 hrs 25 mins
GeForce GTX 550 Ti Nvidia GF116 16,497 41,725 0.40 61 hrs 42 mins
Radeon RX Vega gfx902 AMD raven 11,394 29,000 0.39 61 hrs 5 mins
Radeon APU A4-6000 R2 AMD Mullins 2,519 29,000 0.09 276 hrs 18 mins

PROJECT FOLDING PPD AVERAGES BY CPU (BETA TEST)

CPU Model Make Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
 

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